Papers, explained in our own words

1. Generation of Well-Defined Micro/Nanoparticles via Advanced Manufacturing Techniques for Therapeutic Delivery

Not Fully Listed In The Supplied File; Corresponding Authors Are P.Z. ([email protected]) And S.L. ([email protected])

Conventional micro/nanoparticle synthesis techniques (e.g., emulsion, sol–gel) can produce only a limited number of shapes—mainly spherical or rod-like—and provide poor control over size, cargo loading, and surface properties. These features critically affect particle–cell interactions and in vivo biodistribution, so advanced manufacturing techniques are needed to generate well-defined micro/nanoparticles for improved therapeutic delivery. --- - Size-dependent uptake: 100 nm particles showed 2.5-fold greater uptake by Caco-2 cells than 1 µm particles and 6-fold higher uptake than 10 µm particles. - Size-dependent internalization mechanisms: Particles >500 nm are internalized mainly by phagocytosis; <500 nm by pinocytosis. Particles <200 nm enter via clathrin-coated pits; ~500 nm via caveolae-mediated internalization. ~200 nm particles are more easily routed to lysosomes than ~500 nm particles. - In vivo size effects: >200 nm particles a