Ionizable lipid systems self-assemble around nucleic acid cargo and fuse with the endosomal membrane at the right pH. Fine control of pKa, helper-lipid ratio and PEG density governs both potency and tolerability.
How we work on it
Every programme in this area follows the same staged path: target definition, carrier or formulation engineering, validation in physiologically relevant models, then transfer to continuous-flow GMP production. Read the full technology overview or talk to the team.