1. DNA-Stimulated Cell Death: Implications for Host Defence, Inflammatory Diseases and Cancer
Søren R. Paludan, Line S. Reinert, Veit Hornung
DNA in abnormal cellular compartments (cytosol, endosomes, micronuclei) is a potent danger signal for the innate immune system, primarily known for inducing type I interferons and IL-1β. More recently, it has become clear that cytosolic DNA also triggers various forms of programmed cell death (PCD), but the pathways and biological implications of DNA-stimulated cell death remain incompletely understood. This review addresses the gap in understanding how DNA-sensing pathways engage PCD and how these processes shape host defence, inflammatory diseases, and cancer. --- - AIM2-mediated cell death: Cytosolic DNA triggers AIM2-ASC-dependent pyroptosis via caspase-1 and gasdermin D; in the absence of caspase-1 or with low DNA, ASC recruits caspase-8 to induce apoptosis. - STING-mediated apoptosis: STING can induce apoptosis via an IRF3-BAX complex (RIPA pathway) independent of IRF3 transcriptional activity but requiring TBK1; this pathway oper
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