Discover nano2026ReviewNon-viral Gene DeliveryDrug Delivery
Aadil Kr, Bhange K, Kommineni N, Mishra G, Bunekar N, Jha A, Et Al.
Messenger RNA (mRNA)-based therapeutics have transformed cancer treatment strategies, especially after the success of lipid nanoparticle (LNP)-enabled mRNA vaccines. LNPs are effective non-viral delivery vehicles that protect mRNA, enhance intracellular delivery, and improve therapeutic safety. This review discusses…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Lai Gy, Hsieh Ysy, Lee Mh
Plant-derived herbal medicines remain important sources of bioactive compounds, but their clinical application is often hindered by poor bioavailability and variable pharmacokinetic profiles. Recent studies have identified plant-derived exosome-like nanoparticles (PELNs) as naturally occurring bioactive nanoparticle…
Read the article →Frontiers in immunology2026ReviewNon-viral Gene DeliveryDrug Delivery
Ganjalikhani Hakemi M, Saltanatpori Z, Zhou L, Zeng X, Sun L, Liao Z
Chimeric antigen receptor-engineered natural killer (CAR-NK) cell therapy has emerged as a promising cancer treatment by combining the antigen specificity of CAR engineering with the intrinsic cytotoxicity of NK cells. Compared with CAR-T cell therapy, CAR-NK cells exhibit a lower risk of graft-versus-host disease…
Read the article →Frontiers in pharmacology2026ReviewDrug Delivery
Inam M, Hayat M, Latif F, Ahmed B, Osman A
Endometriosis is a chronic inflammatory condition for which existing treatments, mainly hormonal therapy and surgical intervention, remain insufficient. These approaches are often limited by high recurrence rates, significant side effects, and an inability to effectively target underlying disease mechanisms. This…
Read the article →Discover nano2026ReviewDrug Delivery
Parseghian L, Sanadgol N, Negah Ss, Fahanik-Babaei J, Rafati H
Efficiently delivering therapeutics to the central nervous system (CNS) remains a major challenge in multiple sclerosis (MS), particularly for strategies targeting CNS-resident pathology, neuroprotection, or remyelination. This review provides a delivery- and formulation-centered comparative analysis of CNS drug…
Read the article →Expert opinion on drug delivery2026ReviewDrug Delivery
Hernandez Pa, Moore Cj, Overby Ct, Benoit Dsw
Nanoparticle drug delivery systems (NP DDS) have transformed therapeutic delivery by improving drug stability, extending circulation time, and enabling targeted biodistribution. However, clinical translation remains limited by protein corona formation, immune recognition, and accelerated blood clearance following…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Herdiana Y
Tuberculosis treatment remains prolonged because effective therapy must maintain coordinated multidrug exposure across heterogeneous lesions, bacterial states, and intracellular compartments. Long-acting nanomedicine may reduce adherence-related vulnerability and improve drug delivery, but prolonged release alone do…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Fu L, Wang L, Li H, Li R, Yue X, Cui Y, Et Al.
Metal-organic frameworks (MOFs) can coordinate copper, catalytic sites and therapeutic cargo within one carrier, offering opportunities to control copper exposure and cellular susceptibility. Establishing their contribution to cuproptosis requires evidence connecting these design functions to copper delivery and the…
Read the article →International journal of nanomedicine2026ResearchDrug Delivery
Chen Z, Liu Y, Jiang M, He X, Xiao M, Wu A, Et Al.
Nanoplatform-based combination therapy offers a promising route for enhanced cancer therapy. Despite the advance of nanomedicine, the precise subcellular co-delivery and controlled release of combinatorial therapeutic agents remain a significant challenge. Herein, a near-infrared (NIR)-responsive…
Read the article →Exploration (Beijing, China)2026ReviewDrug Delivery
Lin Yj, Komperda I
Although nanomedicines offer advanced formulation control and physicochemical characterization, clinical translation has been limited. Delivery meta-analyses and late-stage attrition indicate biological validation is often a bottleneck. It must account for context-dependent processes such as protein corona formation…
Read the article →Current drug targets2026ResearchDrug Delivery
Sharma S, Nag P, Vij K, Kalra A, Goel K
Neurological problems are among the world's most significant health issues. Many conditions are considered incurable because current treatments cannot effectively cross the Blood-Brain Barrier (BBB) to exert pharmacological effects. Nanomedicine utilizing various nanoparticles offers a distinct therapeutic approach…
Read the article →ACS applied materials & interfaces2026ResearchNon-viral Gene DeliveryDrug Delivery
Quagliarini E, Petronella F, Digiacomo L, Miglietta S, Buccini L, Mura F, Et Al.
Gene therapy is a cutting-edge strategy for treating, preventing, and potentially eradicating a wide range of diseases. Its success is critically dependent on the transfection efficiency of gene delivery systems. In this context, lipid nanoparticles (LNPs) are widely investigated for the delivery of plasmid DNA…
Read the article →Chembiochem : a European journal of chemical biology2026ReviewDrug Delivery
Joshi N, Semwal P, Rawat B, Kumar R, Oliveira Ms, Rai N, Et Al.
Shikonin (SHK) is a red naphthoquinone produced mainly in the roots of Boraginaceae species and has been investigated for anticancer, anti-inflammatory, antimicrobial, neuroprotective, cardioprotective, hepatoprotective, and wound-healing activities. This review critically integrates botanical sources and…
Read the article →Nanomedicine (London, England)2026ResearchDrug Delivery
Tunc Cu, Saha Sk, Panda Ss, Mori S, Culha M
DNA nanotechnology has emerged as a highly programmable platform in nanomedicine, enabling the fabrication of precise nanoscale architectures for drug delivery, biosensing, gene regulation, immunotherapy, and theranostics. DNA-based nanocarriers offer distinctive advantages, including structural programmability…
Read the article →Current pharmaceutical design2026ResearchDrug Delivery
Babar E, Ur Rehman A, Gul P, Arshad Ms, Shah Ba, Ahmed N
Alzheimer's disease affects millions of people globally; it is an irreversible and incurable disease, characterized by gradual cognitive decline as well as pathophysiological changes including the presence of senile plaques and neurofibrillary tangles. There are several risk factors associated with Alzheimer's…
Read the article →International journal of nanomedicine2026ReviewDrug Delivery
Bu F, Cao Y, Chen F, Wen Y, Xiong L
Reperfusion therapy has transformed acute ischemic stroke care, yet large-vessel recanalization does not ensure capillary reperfusion, preservation of the blood-brain barrier and neurovascular unit (BBB/NVU), or durable neurological recovery. Nanomedicine is still commonly judged by BBB crossing or…
Read the article →Expert review of anti-infective therapy2026ReviewNon-viral Gene DeliveryDrug Delivery
Gawale K, Karawadiya A, Katawale S, Sawarkar S, Omri A
Antimicrobial resistance (AMR) represents a critical global health threat, surpassing the pace of discovery and clinical development of new antimicrobial agents. Therefore, innovative therapeutic strategies are urgently needed to enhance antibiotic efficacy, overcome multidrug-resistant infections, and limit…
Read the article →ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery
He L, Yang L, Ren M, Wang J, Zhao W, Yang C, Et Al.
The Golgi apparatus (GA) has emerged as a promising target for cancer therapy. Commonly, therapeutics are guided to the GA by recognizing specific receptors on the GA membrane. However, the low and heterogeneous expression of these receptors often results in suboptimal targeting efficiency. Here, we present an…
Read the article →The Journal of pharmacy and pharmacology2026ReviewDrug Delivery
Dubey S, Prakash S, Deshwal Rk, Dwivedi M
Cancer remains a major global health challenge despite significant advances in diagnosis and treatment. Conventional therapies, including chemotherapy, radiotherapy, and surgery, are frequently constrained by non-specific drug distribution, systemic toxicity, multidrug resistance (MDR), and limitations in early tumor…
Read the article →Cancers2026ReviewNon-viral Gene DeliveryDrug Delivery
Sescu Va, Condriuc Ips, Spridon Lg, Cadinoiu An, Miron L, Atanase Li, Et Al.
Breast cancer is the most frequently diagnosed malignancy worldwide and remains a major cause of cancer-related mortality among women. Despite advances in screening, molecular classification, and systemic therapies, treatment of advanced and metastatic disease remains challenging because of tumor heterogeneity…
Read the article →ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery
He Y, Wang L, Williams Ap, Valerio Ti, Sun Y, Bowman J, Et Al.
In this study, we developed a library of mRNA lipid nanoparticles (LNPs) containing clinically used ionizable lipids. We surface-modified these nanoparticles with heparosan polysaccharides and systematically compared their performance with conventional poly(ethylene glycol) (PEG)-modified formulations. Our heparosan…
Read the article →ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery
Abbasi S, Bockley Km, Dohr J, Chen E, Carter Dm, Berlinicke Ca, Et Al.
Active targeting can improve the efficacy of mRNA therapeutics, but ligand-mediated targeting with lipid nanoparticles (LNPs) remains challenging. Here, we studied the impact of polyethylene glycol (PEG)-lipid composition and triantennary N-acetylgalactosamine (TriGalNAc)-modification on the hepatic delivery…
Read the article →Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery
Jacobs W, De Zwaan K, Rutten L, Van Wessel T, Boltje Tj, Cano Lq, Et Al.
Non-viral nanocarriers for oligonucleotide delivery have enormous therapeutic potential, but the factors determining cell type-specific uptake remain incompletely understood. One major cell surface component that delivery vectors encounter is the glycocalyx. While membrane glycans are established interactors for many…
Read the article →ACS Nano2021ReviewDrug Delivery
Paula M. Cevaal, Abdalla Ali, Ewa Czuba-Wojnilowicz, Jori Symons, Sharon R. Lewin, Christina Cortez-Jugo, Frank Caruso
T cells are attractive targets for immunotherapy, cancer, HIV, autoimmunity, and inflammation, but nanoparticle delivery to T cells remains a major technological challenge due to their nonphagocytic nature and multiple physiological barriers. There is a need for rational design principles for in vivo T cell-targeting…
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