Molecular therapy. Advances2026ResearchNon-viral Gene Delivery
1. Bovine AAV: A promising vector for pulmonary gene therapy
Ivan Dc, Dubost V, Israel L, Weinmann J, Ungan D, Carbonetti N, Et Al.
Efficient systemic delivery to the lung remains a major barrier for adeno-associated virus (AAV)-mediated pulmonary gene therapy, particularly when pre-existing immunity limits the use of conventional capsids. Here, we evaluated Bovine AAV, a phylogenetically divergent capsid, as a candidate vector for lung-directed…
- AAV cross-reactivity
- AAV manufacturing
- AAV seroprevalence
- bovine AAV
- lung tropism
- neutralizing antibodies
- pre-existing immunity
- pulmonary endothelial cells
- pulmonary gene therapy
- systemic gene transfer