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Publications

Reviews, data and technical documents

Our literature reviews, company and field news, and downloadable white papers, application notes and conference posters.

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White papers

Design rules and platform overviews for formulation scientists and programme leads.

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  • BrilliantCore™ platform technical briefFormulation principles, lipid library composition and characterisation data for our ionisable carrier series.PDF · 2 pages ↓
  • Engineering endosomal escape: design rules for ionisable lipid nanoparticlesWhy most internalised cargo never reaches the cytosol, and how pKa, lipid shape and helper lipids change that.PDF · 2 pages ↓
  • Targeting ligand selection for nanocarriersA practical comparison of antibody fragments, affibodies, aptamers and peptides for surface functionalisation.PDF · 2 pages ↓
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Application notes

Step-by-step methods with acceptance criteria you can run in your own laboratory.

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  • Controlling LNP size and PDI with microfluidic mixingHow total flow rate and flow-rate ratio set particle size, with a worked design-of-experiments example.PDF · 1 page ↓
  • Measuring mRNA encapsulation efficiency with a RiboGreen assayA plate-based protocol with Triton X-100 lysis, standard curves and common sources of error.PDF · 2 pages ↓
  • Testing pH-triggered charge reversal in tumour-responsive carriersZeta-potential titration and uptake assays that confirm a carrier switches charge in mildly acidic conditions.PDF · 1 page ↓
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Conference posters

Research summaries presented at scientific meetings, in poster format.

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  • pKa tuning of ionisable lipids and cytosolic delivery of siRNAPoster summarising how apparent pKa relates to gene silencing in hepatocyte and tumour cell models.PDF · 1 page ↓
  • A multiplexed quantum-dot biomarker panel for point-of-care usePoster describing the optical design and analytical performance of a twelve-channel quantum-dot immunoassay.PDF · 1 page ↓
Publications | Brilliant Blue Biosciences