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Showing 1–1 of 1 articles · Keyword: APOBEC3B siRNA Clear keyword

International journal of biological macromolecules2026ResearchNon-viral Gene Delivery

1. Hyaluronic acid-engineered NLCs as a macromolecular delivery platform for APOBEC3B siRNA and gemcitabine in triple-negative breast cancer: In vitro to in ovo assay

Quadir Ss, Tonge L, Ross K, Swadi R, Joshi G, Saleem I

Triple-negative breast cancer (TNBC) lacks targetable receptors and has poor clinical outcomes. This study combines hyaluronic acid (HA), a CD44-binding glycosaminoglycan, with APOBEC3B siRNA to engineer HA-functionalised nanostructured lipid carriers (HA-NLCs) that co-deliver gemcitabine hydrochloride (Gem HCl) and…

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