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Showing 1–1 of 1 articles · Keyword: Auditory safety Clear keyword

Biochemistry and biophysics reports2026ResearchNon-viral Gene Delivery

1. AAV8-mediated CasRx delivery and expression in the cochlea and cochlear nucleus of mice

Zhou S, Huang T, Yao W, Huang S, Jiang J, Liao H, Et Al.

CRISPR/Cas9-based genome editing has made substantial progress in recent years and has enabled the treatment of a variety of genetic diseases, including hearing loss in congenitally deaf mice. However, successful gene editing for hereditary deafness may still induce off-target mutations in genomic DNA, which limits…

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