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Research Review

Showing 25–25 of 25 articles · Keyword: CRISPR Clear keyword

Nature Reviews Genetics2014ReviewNon-viral Gene Delivery

25. Non-viral vectors for gene-based therapy

Yin H, Kanasty Rl, Eltoukhy Aa, Vegas Aj, Dorkin Jr, Anderson Dg.

Gene-based therapy has potential to treat a wide range of diseases, but clinical success is limited by delivery barriers. Viral vectors, while efficient, carry risks of carcinogenesis, immunogenicity, broad tropism, limited packaging capacity, and manufacturing difficulties. Non-viral vectors offer improved safety…

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