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Research Review

Showing 1–1 of 1 articles · Keyword: Cre recombinase Clear keyword

Frontiers in immunology2026ResearchNon-viral Gene DeliveryDrug Delivery

1. An inducible human LDLR transgenic mouse model for enhanced lentiviral gene delivery to murine immune cells

Li J, Goncalves B, Melamed G, O'neill D, Cozzone R, Iuliucci S, Et Al.

Lentivirus (LV)-based manipulation of immune cells is a commonly used approach in cell therapies. However, the most frequently used Vesicular Stomatitis Virus Glycoprotein (VSV-G) pseudotyping approach is inefficient to support LV gene delivery of mouse immune cells due to the lack of an optimal entry receptor. Here…

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