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586 articles

Research Review

Showing 1–1 of 1 articles · Keyword: accelerated blood clearance Clear keyword

ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Poly(acrylamido) PEG-Alternative Lipids Rescue mRNA Efficacy during Repeated Dosing and Enhance Immune Cell Delivery

Fiedler Bm, Galley C, Strimaite M, Cheng Nm, Mahmoudi N, Feng Z, Et Al.

Following the successes of the messenger RNA (mRNA) lipid nanoparticle (LNP) vaccines against COVID-19, mRNA-LNPs are being explored for varied multidose applications including cancer immunotherapies and protein replacement therapies. LNPs rely on poly(ethylene glycol)-lipid (PEG-lipid) coatings for stability, but…

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