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Research Review

Showing 1–1 of 1 articles · Keyword: bis(phosphoramidate diester) Clear keyword

Nano letters2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Bis(phosphoramidate diester)-Based Ionizable Lipids for Highly Efficient Lung-Selective mRNA Delivery via Intercellular Transport

Liu H, Yang B, Chen S, Li Y, Zhang Y, Huang Y, Et Al.

Highly efficient lung-selective mRNA delivery is pivotal for advancing mRNA-based targeted therapy. Here, we report bis(phosphoramidate diester)-based ionizable cationic lipids (bpLs) for lung-specific mRNA delivery via a distinct intercellular transport mechanism. A bpL library is synthesized by modular headgroups…

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