1. Phenolic Hydroxyl-Containing Lipid Nanoparticles Enable Codelivery of HPV Peptide Antigens and Manganese Adjuvant for Cancer Immunotherapy
Hou S, Zhou D, Zhang Y, Li Y, Fan D, Hu Y, Et Al.
Therapeutic peptide vaccines against HPV-associated cancers are often limited by insufficient immunogenicity and inefficient intracellular delivery. Here, we develop a phenolic hydroxyl-containing lipid nanoparticle (EMT@LNP) as a nanomedicine platform for the coordinated codelivery of HPV16 E6/E7 peptide antigens…
- HPV16 E6/E7
- cancer nanovaccine
- lipid nanoparticles
- lymph node delivery
- manganese adjuvant
- tumor immunotherapy
