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A quick squeeze helps CRISPR turn skin cells into neurons more efficiently

Human cells hold about two meters (6.6 feet) of DNA, folded and compacted to fit inside a nucleus. That packing is essential for life, but it creates a problem for scientists. Some of the genes that control a cell's identity are buried so deep in tightly packed DNA that gene-targeting tools such as CRISPR activation, or CRISPRa, struggle to reach them.

Published by
Phys.org
Evidence type
Laboratory

Human cells hold about two meters (6.6 feet) of DNA, folded and compacted to fit inside a nucleus. That packing is essential for life, but it creates a problem for scientists. Some of the genes that control a cell's identity are buried so deep in tightly packed DNA that gene-targeting tools such as CRISPR activation, or CRISPRa, struggle to reach them.

This item was selected automatically by our daily literature and news monitor because it matches the topics we follow. Read the full story at Phys.org.

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A quick squeeze helps CRISPR turn skin cells into neurons more efficiently | Brilliant Blue Biosciences