Human Argonaute 2 is a programmable targeting domain for RNA editing
ALTER is a programmable RNA base editor built entirely from human proteins. By using human AGO2 instead of bacterial CRISPR–Cas proteins, ALTER mitigates a key risk factor for harmful immune responses in therapeutic applications while also proving generally more effective than dCas13-based editors.
- Published by
- Nature Biotechnology
- Evidence type
- Laboratory
ALTER is a programmable RNA base editor built entirely from human proteins. By using human AGO2 instead of bacterial CRISPR–Cas proteins, ALTER mitigates a key risk factor for harmful immune responses in therapeutic applications while also proving generally more effective than dCas13-based editors.
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