Nucleic Acid Binding, Loading & Release
Surface Plasmon Resonance (SPR) / Quartz Crystal Microbalance (QCM-D)
Real-time binding kinetics between nanocarriers and biomolecules.
Purpose
To study real-time binding kinetics between nanocarriers and biomolecules (e.g., nucleic acids, serum proteins, receptors).
Standard protocol
Protocol: SPR for binding analysis
- 1
Immobilise the ligand (e.g., DNA) on the sensor chip.
- 2
Inject the carrier solution (e.g., cationic polymer) at various concentrations.
- 3
Monitor the response in real time.
- 4
Analyse
- Association rate (ka).
- Dissociation rate (kd).
- Affinity (KD = kd/ka).
Let's engineer the next delivery breakthrough together
We co-develop nanocarrier and biosensing programs with pharma, biotech and academic groups — from target selection through GMP supply.