Recent Advances in Lipid Nanoparticles: Nucleic Acid Therapeutics and Targeting Strategies
S Sarmah, S Baidya, M DeDOI 10.1002/smll.202506812
Summary
This review surveys lipid nanoparticle composition, ionizable lipid synthesis and strategies to target delivery of fragile RNA therapeutics while addressing tissue selectivity and immune activation.
Purpose: RNA therapeutics require carriers that protect their cargo and improve delivery to the intended tissue.
Approach: A review of lipid nanoparticle composition, nucleic acid applications and targeting approaches rather than a new experimental comparison.
Key findings: The review identifies tissue selectivity, payload capacity and immune activation as priorities in the development of LNPs for mRNA and siRNA delivery. Ionizable lipid chemistry and targeting mechanisms are discussed as design tools.
Interpretation: Precision delivery requires attention to both carrier composition and biological targeting.
Limitations: The review does not establish comparative clinical outcomes for the proposed strategies.
Related articles
Advances in Colloid and Interface Science
Advances in lipids design for LNP-mediated DNA and RNA delivery
BioDrugsRecent Developments in Lipid Nanoparticle-Mediated Delivery of Biotherapeutics and Gene Therapy Across the Blood-Brain Barrier
Molecular Therapy Methods & Clinical DevelopmentRational design of lipid nanoparticles for enabling gene therapies
Let's engineer the next delivery breakthrough together
We co-develop nanocarrier and biosensing programs with pharma, biotech and academic groups — from target selection through GMP supply.