Articles

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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

691 articles

Research Review

Showing 1–2 of 2 articles · Keyword: Active targeting Clear keyword

Neoplasia (New York, N.Y.)2026ResearchDrug Delivery

1. αvβ3 integrin recycling is associated with the intracellular trafficking and efflux of cRGDfK-modified PLGA nanoparticles

Zhu J, Chen S, Yu L, Xu R, Sun H, Wang X, Et Al.

Understanding the cellular transport mechanisms of active-targeting nanocarriers is essential for improving their therapeutic performance. In this study, cRGDfK-modified poly(lactic-co-glycolic acid) nanoparticles (cRGDfK-PLGA-NPs) were developed as an αvβ3 integrin-targeted delivery system, and their cellular…

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ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery

2. Boosting Ligand-Mediated Hepatic mRNA Delivery and Gene Editing Through Coordinated Pairing of Polyethylene Glycol-Modified Lipids

Abbasi S, Bockley Km, Dohr J, Chen E, Carter Dm, Berlinicke Ca, Et Al.

Active targeting can improve the efficacy of mRNA therapeutics, but ligand-mediated targeting with lipid nanoparticles (LNPs) remains challenging. Here, we studied the impact of polyethylene glycol (PEG)-lipid composition and triantennary N-acetylgalactosamine (TriGalNAc)-modification on the hepatic delivery…

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