Advanced drug delivery reviews2026ReviewDrug Delivery
1. Anti-PEG antibodies in drug delivery: From origins to mitigation strategies
Ding T, Fu J, Zhao X, Lu H, Zhan C
Poly(ethylene glycol) (PEG) is a cornerstone excipient in drug delivery, widely used to prolong circulation duration and improve the therapeutic efficacy of protein therapeutics and nanomedicines. However, both pre-existing and treatment-induced anti-PEG antibodies have been increasingly recognized during clinical…
- Binding patterns
- Biological effects
- Complement activation
- Detection methodologies
- Emerging strategies
- Immunogenicity
- Poly(ethylene glycol)
- Pre-existing antibodies
