Frontiers in drug delivery2026ResearchDrug Delivery
1. Maleimide availability in thiol-maleimide peptide conjugation on PEGylated liposomes: a reactive-site accounting framework illustrated using hepatic drug-delivery systems
Maroof K, Genç R
Peptide-targeted PEGylated liposomes are a widely investigated active-targeting strategy for hepatocellular carcinoma (HCC) and other hepatic indications. A critical but underreported formulation variable is effective maleimide availability: the number of outward-facing, unhydrolysed, sterically accessible maleimide…
- DSPE-PEG-maleimide
- conjugation efficiency
- hepatic nanomedicine
- hepatocellular carcinoma
- maleimide availability
- peptide-targeted liposomes
- thiol-maleimide conjugation
