Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 73–76 of 76 articles · Keyword: Endosomal escape Clear keyword

Bioorganic & Medicinal Chemistry (inferred from journal style; exact journal not stated in supplied excerpt)2007ResearchNon-viral Gene Delivery

73. Structural Advantage of Dendritic Poly(L-lysine) for Gene Delivery into Cells

Masato Yamagata, Takahito Kawano, Kouhei Shiba, Takeshi Mori, Yoshiki Katayama, Takuro Niidome

Gene carriers are often studied individually under different assay conditions, making direct structure–function comparisons difficult. The study compared dendritic poly(L-lysine) (KG6) and linear poly(L-lysine) (PLL) within the same experimental system to identify how carrier architecture affects DNA complex…

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2001ReviewNon-viral Gene Delivery

74. Design and gene delivery activity of modified polyethylenimines

Kircheis, R.; Wightman, L.; Wagner, E

PEI is one of the most effective non-viral gene delivery polymers, but its efficacy, toxicity, and in vivo behaviour depend strongly on molecular weight, branching, particle size, surface charge, and modifications. This review addresses how PEI/DNA complexes can be modified with targeting ligands, shielding agents…

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1999ReviewNon-viral Gene Delivery

75. Poly(ethylenimine) and its role in gene delivery

Godbey, W. T.; Wu, K. K.; Mikos, A. G

Gene therapy still lacks safe and efficient delivery vectors. PEI has emerged as a promising non-viral polycation because it condenses DNA and mediates endosomal escape, but its transfection mechanism, targeting potential, and toxicity require clearer understanding. This review summarises PEI chemistry, PEI/DNA…

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ResearchNon-viral Gene Delivery

76. pH-Responsive Polydopamine Nanoparticles for Photothermally Promoted Gene Delivery

Peng Zhang, Qinan Xu, Xinfang Li, Youxiang Wang

Non-viral gene vectors must overcome multiple extracellular and intracellular barriers: stability in blood, efficient cellular uptake, endosomal escape, and intracellular gene release. Stimuli-responsive carriers can address some barriers, but a carrier capable of overcoming multiple barriers simultaneously is still…

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