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421 articles

Keyword: Extracellular vesicles (EVs)Clear keyword

Molecular neurobiology2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Advances in Extracellular Vesicle-Based Innovative Drugs Targeting Alzheimer's Disease

Liu S, Lu J, Liu J, Liu H, Liu Z, Yang D, Et Al.

The scarcity of effective therapies for Alzheimer's disease (AD) underscores the urgent need for innovative strategies. This review focuses on the targeted delivery of engineered small extracellular vesicles (sEVs, 30-150 nm). By capitalizing on their intrinsic properties as natural nanocarriers-including low immunogenicity and excellent biocompatibility-these EVs can be engineered to co-deliver therapeutic cargoes such as specific miRNAs, neurotrophic factors (e.g., BDNF), and nucleic acid modalities (e.g., siRNA/ASO targeting BACE1).

Alzheimer’s disease (AD)Blood-brain barrier (BBB)Extracellular vesicles (EVs)Intranasal delivery

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