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Research Review

Showing 1–1 of 1 articles · Keyword: LNP stability Clear keyword

International journal of pharmaceutics: X2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Enhanced stability of siRNA-loaded lipid nanoparticles during lyophilization via acetyl-arginine and disaccharides

Kim Kh, Mainali A, Pih Sh, Jung Hs, Kim Hj, Kim Na, Et Al.

RNA-loaded lipid nanoparticles (LNPs) are highly sensitive to temperature fluctuations, which present significant challenges for storage and transportation. Lyophilization is a potential strategy to enhance storage stability; however, the freeze-drying process can subject nanoparticles to stresses that may alter…

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