Discover nano2026ReviewNon-viral Gene DeliveryDrug Delivery
Aadil Kr, Bhange K, Kommineni N, Mishra G, Bunekar N, Jha A, Et Al.
Messenger RNA (mRNA)-based therapeutics have transformed cancer treatment strategies, especially after the success of lipid nanoparticle (LNP)-enabled mRNA vaccines. LNPs are effective non-viral delivery vehicles that protect mRNA, enhance intracellular delivery, and improve therapeutic safety. This review discusses…
Read the article →Molecular cancer2026ResearchNon-viral Gene DeliveryDrug Delivery
Ni J, He G, Wang H, Qin Y, Guo J, Wang Y, Et Al.
Proficient mismatch repair/microsatellite-stable colorectal cancer (pMMR/MSS CRC), which represents the majority of clinical cases, exhibits low tumor mutational burden and minimal responsiveness to immune checkpoint blockade. Disrupting the MMR system has been shown to resensitize pMMR/MSS CRC to immune…
Read the article →Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology2026ReviewNon-viral Gene Delivery
Schauberger Em, Phillips Ja
The management of allergic and immunologic diseases has long centered on symptom management rather than disease modification. Conventional pharmacotherapy controls manifestations of the immune dysregulation but does little to treat the underlying cause. Newer monoclonal and small molecule therapies target downstream…
Read the article →International journal of nanomedicine2026ReviewNon-viral Gene DeliveryDrug Delivery
Fu M, Zhao R, Cao Y, Nan Y, Fan L, Liu Z
Gynecological cancers, including ovarian, cervical, and endometrial cancers, remain major contributors to female morbidity and mortality worldwide. Conventional treatments-surgery, chemotherapy, and radiotherapy-have improved outcomes, but advanced or recurrent disease is still associated with poor prognosis…
Read the article →Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery
Kim M, Jeong M, Chatterjee S, Vaidya A, Pham C, Lee Sm, Et Al.
Fibroblast activation and differentiation into myofibroblasts drive excessive extracellular matrix deposition and irreversible scarring in pulmonary fibrosis, such as idiopathic pulmonary fibrosis (IPF), underscoring the need for therapies that directly target fibroblast activation. Here, we apply engineered…
Read the article →Advanced science (Weinheim, Baden-Wurttemberg, Germany)2026ResearchNon-viral Gene DeliveryDrug Delivery
Sarode A, Patel P, Derosa F, Karve S, Gervier R
The clinical translation of mRNA-lipid nanoparticle (mRNA-LNP) therapeutics is constrained by limited stability of liquid formulations, necessitating ultra-cold storage and restricting global accessibility. Here, we report a spray-dried dry powder platform for mRNA-LNPs that overcomes these limitations while enabling…
Read the article →European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V2026ResearchDrug Delivery
Da Costa Rodrigues T, Kola Ns, Patel D, Ibrahim A, Ma'aruf Sy, Haddadi A, Et Al.
Subunit vaccines are typically given through injections, which limits mucosal immunity. Most adjuvants do not stimulate mucosal responses but using lipid nanoparticles (LNPs) encapsulating polyinosinic-polycytidylic acid (poly(I:C)), a toll-like receptor 3 agonist, could enhance the immune response in the lungs. We…
Read the article →Biomacromolecules2026ResearchDrug Delivery
Hall Cb, Tan L, Okai Dna, Dobler S, Adigun R, Okuwobi Cb, Et Al.
Herein, we characterize a class of PAMAM/acyl synthetic lipids and their self-assembled nanostructures. We explicitly determined the impact of hydrocarbon length, saturation, and synthetic lipid volume on the properties of the self-assembled, single-component nanostructure. The synthesis of the PAMAM-acyl lipid…
Read the article →Molecular medicine reports2026ReviewNon-viral Gene Delivery
Qin R, Hu X, Jiang W, Wang J, Zheng M, Zhang Z, Et Al.
Genetic epilepsy, for which the molecular mechanisms are relatively well defined in numerous monogenic forms, represents an attractive model for the transition from symptomatic seizure control to mechanism‑driven correction. However, gene therapy strategies differ in their mechanisms of action, adaptability to…
Read the article →International journal of pharmaceutics: X2026ResearchNon-viral Gene DeliveryDrug Delivery
Kim Kh, Mainali A, Pih Sh, Jung Hs, Kim Hj, Kim Na, Et Al.
RNA-loaded lipid nanoparticles (LNPs) are highly sensitive to temperature fluctuations, which present significant challenges for storage and transportation. Lyophilization is a potential strategy to enhance storage stability; however, the freeze-drying process can subject nanoparticles to stresses that may alter…
Read the article →MedComm2026ReviewNon-viral Gene DeliveryDrug Delivery
Kamra K, Gaur S, Singh J
Respiratory diseases remain major causes of morbidity and mortality; however, inadequate pulmonary drug exposure and systemic toxicity continue to limit treatment efficacy. Inhaled nanomedicines offer opportunities for localized, sustained, and targeted therapy. This review examines how disease biology informs…
Read the article →ACS applied materials & interfaces2026ResearchNon-viral Gene DeliveryDrug Delivery
Quagliarini E, Petronella F, Digiacomo L, Miglietta S, Buccini L, Mura F, Et Al.
Gene therapy is a cutting-edge strategy for treating, preventing, and potentially eradicating a wide range of diseases. Its success is critically dependent on the transfection efficiency of gene delivery systems. In this context, lipid nanoparticles (LNPs) are widely investigated for the delivery of plasmid DNA…
Read the article →European journal of haematology2026ReviewNon-viral Gene DeliveryDrug Delivery
Morabito F, Martino Ea, Bruzzese A, Amodio N, Caserta S, Lucia E, Et Al.
mRNA-based vaccines are emerging as a promising platform for cancer immunotherapy, including in hematologic malignancies. Current vaccine development has largely focused on antigen selection, mRNA engineering, lipid nanoparticle (LNP) formulation, and combination with established immunotherapies. However, increasing…
Read the article →Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery
Kehrein J, Reus E, Holick Ct, Mummel S, Ates I, Wang X, Et Al.
Delivering therapeutic mRNA relies on lipid nanoparticles (LNPs). Finding optimal process parameters for new lipid combinations in LNP formulations remains a challenge. We used an automated, self-regulating microfluidic formulation platform developed for PEG-containing LNPs that actively changes process parameters to…
Read the article →Journal of ovarian research2026ResearchNon-viral Gene DeliveryDrug Delivery
Xu Jy, Liu K, Chen Ly, Liu C, Chen Dy, Wu Sg, Et Al.
Ovarian cancer is the foremost cause of mortality among gynecologic malignancies. Paclitaxel (PTX) exerts a significant therapeutic effect on ovarian cancer by targeting microtubules and impeding the cell cycle progression during the mitosis phase. MOB kinase activator 1 A (MOB1A) has been proven to regulate the…
Read the article →Molecular pharmaceutics2026ResearchNon-viral Gene DeliveryDrug Delivery
Gul S, Vergnaud J, Wang Q, Hery M, Dumont F, Tran P, Et Al.
Tumor-associated macrophages (TAMs) are central regulators of the tumor microenvironment (TME). Their polarization state can critically influence tumor development and treatment resistance. In the TME, the pro-tumor M2-like phenotype is the most prevalent among TAMs and contributes to tumor progression by promoting…
Read the article →ACS applied materials & interfaces2026ResearchNon-viral Gene DeliveryDrug Delivery
Yuan Y, Li G, Liu Y, Liu L, Hu C, Qi H, Et Al.
Lipid nanoparticles (LNPs) play a pivotal role in mRNA-based therapy; however, achieving targeted delivery remains challenging. We developed an LNP platform integrating peptide amphiphiles (PAs) to exploit their dual bioactivity and electrostatic tunability. Two PAs, cationic C16TAT (derived from a cell-penetrating…
Read the article →Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery
Olsen Al, Brandt Cbv, Larsen Rk, Fonager Sv, Zubia-Aranburu J, Haskó J, Et Al.
Efficient and cell-type-specific delivery remains a major barrier to CRISPR-based genome editing in vascular endothelial cells. Here, we systematically evaluate lipid nanoparticle (LNP)-mediated mRNA and CRISPR delivery in human umbilical vein endothelial cells (HUVECs). While a conventional SM-102-based LNP…
Read the article →Expert opinion on drug delivery2026ReviewDrug Delivery
Gelperina S, Wacker Mg
Apolipoprotein E (apoE) plays a context-dependent role in nanomedicine for central nervous system drug delivery. It can facilitate cerebral endothelial recognition and increase brain exposure in nanoparticle systems while simultaneously promoting hepatic uptake, challenging its traditional interpretation as a…
Read the article →The Journal of pharmacology and experimental therapeutics2026ResearchNon-viral Gene DeliveryDrug Delivery
Nazir N, Gajjar Tb, Hanumanthayya M, Bainsal N, Singhal D, Smerat A, Et Al.
mRNA immunotherapy holds transformative potential in oncology, yet single-agent approaches frequently fail against immunosuppressive tumor microenvironments (TMEs). Bioactivatable co-delivery of immunogenic chemotherapy alongside mRNA offers mechanistically synergistic advantages, yet coformulation of hydrophobic…
Read the article →Pharmaceutics2026ReviewDrug Delivery
Syed Hashim Sa
Clinical translation of lipid nanomedicines in oncology is limited by biological barriers and by an interpretive challenge: tumour accumulation and cellular uptake are often used as proxies for delivery even when pharmacologically competent cargo, meaning cargo capable of producing its intended molecular effect, has…
Read the article →ACS applied bio materials2026ResearchDrug Delivery
Hou S, Zhou D, Zhang Y, Li Y, Fan D, Hu Y, Et Al.
Therapeutic peptide vaccines against HPV-associated cancers are often limited by insufficient immunogenicity and inefficient intracellular delivery. Here, we develop a phenolic hydroxyl-containing lipid nanoparticle (EMT@LNP) as a nanomedicine platform for the coordinated codelivery of HPV16 E6/E7 peptide antigens…
Read the article →International journal of molecular sciences2026ReviewNon-viral Gene DeliveryDrug Delivery
Rachamala Hk, Angom Rs, Marepally S
In recent years, lipid nanoparticles (LNPs) have shown great promise as highly flexible delivery systems for cancer vaccines, which enable effective cargo delivery and allow for controlling their distribution, cell-targeting ability and immunogenicity. Innovations in ionizable lipid chemistry, biodegradable…
Read the article →Advanced healthcare materials2026ResearchNon-viral Gene DeliveryDrug Delivery
Ren Y, Wang Q, Li P, Zhang Z, Wei G, Tan Y, Et Al.
Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are…
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