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Showing 1–1 of 1 articles · Keyword: Large insertion Clear keyword

Methods in molecular biology (Clifton, N.J.)2027ResearchNon-viral Gene Delivery

1. Large Insertion Using Template-Jumping Prime Editing

Zheng C, Xue W

Prime editors (PEs) are advanced gene-editing tools capable of a wide spectrum of genomic modifications, offering significant potential for gene therapy. The template-jumping prime editing (TJ-PE) system employs template-jumping prime editing guide RNAs (TJ-pegRNAs) with a dual primer binding site (PBS) sequence. One…

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