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571 articles

Research Review

Showing 1–1 of 1 articles · Keyword: Mg(2+)-mediated mRNA folding Clear keyword

Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery

1. mRNA folding facilitates efficient and spleen-targeted delivery by highly branched poly(β-amino ester)s

Li H, Sun Q, Wang S, Xu W, Shi L, Yang Y, Et Al.

Messenger RNA (mRNA)-based therapeutics hold great promise in preventing and treating various diseases. However, the instability and high immunogenicity of raw mRNA molecules, along with the inefficient delivery vectors, strictly limited the proteins translation and therapeutic applications. In this work, we…

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