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Research Review

Showing 1–1 of 1 articles · Keyword: Molecular dynamics Clear keyword

Materials today (Kidlington, England)2026ResearchNon-viral Gene Delivery

1. Chemical topology of lipo-amino fatty acid mRNA carriers triggers distinct lipid bulk phases and endosomal escape mechanisms ☆

Grau M, Kostyurina E, Seidl J, Martini N, Winkeljann B, Merkel Om, Et Al.

LAF-Stp xenopeptides (XPs) comprising lipoamino fatty acid (LAF) units connected with the tetraethylene pentamine derived polyamino acid Stp were identified as a novel class of amphiphilic mRNA carriers. A 'chameleon-like' polarity switch is observed upon transition from neutral physiological to endosomal acidic pH…

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