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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

706 articles

Research Review

Showing 1–2 of 2 articles · Keyword: Nucleic acids Clear keyword

Cancer Biology & Therapy2014ResearchNon-viral Gene Delivery

1. Liposome-Coated Lipoplex-Based Carrier for Antisense Oligonucleotides

Paulina Wyrozumska, Justyna Meissner, Monika Toporkiewicz, Marta Szarawarska, Kazimierz Kuliczkowski, Maciej Ugorski, Marta A. Walasek & Aleksander F. Sikorski

Most cancer gene therapy research has focused on solid tumours, while blood cancers such as leukaemia and lymphoma have received less attention. There is a need for a lipid carrier that protects antisense oligonucleotides or plasmid DNA from enzymatic degradation, is stable in serum, has low toxicity, and can…

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Biochimica et Biophysica Acta (BBA) - Biomembranes2005ResearchNon-viral Gene Delivery

2. Uptake of cell-penetrating peptides is dependent on peptide-to-cell ratio rather than on peptide concentration

Mattias Hallbrink, Johannes Oehlke, Gisela Papsdorf, Michael Bienert

Cell-penetrating peptides (CPPs) efficiently translocate across plasma membranes and are promising delivery vectors for therapeutic macromolecules. However, the influence of cell state, density, and peptide-to-cell ratio on CPP uptake and degradation has received little attention. Understanding whether CPP uptake is…

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