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586 articles

Research Review

Showing 1–1 of 1 articles · Keyword: PEG-free Clear keyword

ACS nano2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Lipid Nanoparticle Surface Engineering with Heparosan Polysaccharides Enhances mRNA Efficacy via Reduced Endosomal Retention

He Y, Wang L, Williams Ap, Valerio Ti, Sun Y, Bowman J, Et Al.

In this study, we developed a library of mRNA lipid nanoparticles (LNPs) containing clinically used ionizable lipids. We surface-modified these nanoparticles with heparosan polysaccharides and systematically compared their performance with conventional poly(ethylene glycol) (PEG)-modified formulations. Our heparosan…

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