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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

721 articles

Research Review

Showing 49–51 of 51 articles · Keyword: Poly(beta-amino ester) Clear keyword

Accounts of Chemical Research2008ReviewNon-viral Gene Delivery

49. A Combinatorial Polymer Library Approach Yields Insight into Nonviral Gene Delivery

Green, J. J.; Langer, R.; Anderson, D. G

Gene therapy has enormous therapeutic potential, but delivery remains the central bottleneck. Viral vectors are efficient but carry serious safety, immunogenicity, manufacturing, and cargo-capacity limitations. Nonviral vectors are safer and more scalable but typically orders of magnitude less effective. This Account…

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Bioconjugate Chemistry2006ResearchNon-viral Gene Delivery

50. Biodegradable Polymeric Vectors for Gene Delivery to Human Endothelial Cells

Jordan J. Green, Julie Shi, Eugene Chiu, Elizaveta S. Leshchiner, Robert Langer, Daniel G. Anderson

Effective and safe gene delivery to primary endothelial cells in the presence of serum proteins is particularly challenging. Endothelial cells are important targets for cardiovascular disease and cancer, but existing nonviral vectors have low efficacy and/or cytotoxicity under serum-containing conditions. C32…

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Synthesis of Poly(β-amino esters) Optimized for Highly Effective Gene Delivery.2003ResearchNon-viral Gene Delivery

51. Synthesis of Poly(â-amino ester)s Optimized for Highly Effective Gene Delivery

Akinc, A., Anderson, D. G., Lynn, D. M., & Langer, R. (2003).

Nonviral polymeric gene delivery vectors need systematic optimisation of nonstructural factors—polymer molecular weight, chain end-group, and polymer/DNA ratio—that strongly influence transfection, cytotoxicity, and DNA complexation. These factors had not been comprehensively studied together for poly(β-amino…

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