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Showing 1–1 of 1 articles · Keyword: Postmenopausal osteoporosis Clear keyword

Bioactive materials2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Osteoporosis treatment via programmed delivery of IRF5 siRNA to macrophages in bone tissue combined with ROS scavenging

Chen Z, Wu J, Zhu Y, Tan A, Deng J, Niu Y, Et Al.

Postmenopausal osteoporosis (PO) is not merely a consequence of increased osteoclast activity. Estrogen deficiency induces oxidative stress and pro-inflammatory M1 macrophage polarization in bone tissue, thereby sustaining osteoclastogenic stimuli and pathological bone resorption. Interferon regulatory factor 5…

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