Advanced materials (Deerfield Beach, Fla.)2026ResearchDrug Delivery
1. Charge-Reversed Lipid Nanoparticles Enable Encapsulation of Pt 2 L 4 Nanocages for In vivo Anti-Cancer Treatment
Knol Ra, Hu B, Bobylev Eo, Farber M, Laan Pcm, Kock Tjf, Et Al.
Inorganic anticancer drugs such as cisplatin remain central to chemotherapy but are limited by poor tumor selectivity, rapid clearance, and off-target toxicity. We recently developed cationic Pt 2 L 4 nanocages with 12-fold higher anticancer activity than cisplatin in PC-3M-Pro4 cells in vitro, but their positive charge causes rapid extravasation and renal clearance in vivo. Here, we re-engineer lipid nanoparticles (LNPs) into charge-reversed lipid nanoparticles (revLNPs) capable of efficiently encapsulating cationic Pt 2 L 4 nanocages.
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