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601 articles

Research Review

Showing 1–1 of 1 articles · Keyword: Self-regulation Clear keyword

Journal of controlled release : official journal of the Controlled Release Society2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Exploring lipid nanoparticle design spaces using self-regulating microfluidic machines and multiplexed in vivo biodistribution

Kehrein J, Reus E, Holick Ct, Mummel S, Ates I, Wang X, Et Al.

Delivering therapeutic mRNA relies on lipid nanoparticles (LNPs). Finding optimal process parameters for new lipid combinations in LNP formulations remains a challenge. We used an automated, self-regulating microfluidic formulation platform developed for PEG-containing LNPs that actively changes process parameters to…

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