Papers, explained in our own words

1. Transcription activator-like effector base editing delivered by a targeted lipid nanoparticle for therapy of lung cancer

Chen Y, Li P, Xie Y, Wujieti B, Cui W, Zhang H, Et Al.

Lung cancer is the leading cause of cancer-related deaths worldwide. Among them, non-small cell lung cancer (NSCLC) accounts for approximately 85% of all cases, while the mutation of KRAS oncogene plays a crucial role in its formation and metastasis. Here, we report a transcription activator-like effector (TALE) base…

• Gene editing
• KRAS oncogene
• NSCLC
• TALE base editor
• Targeted LNP