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406 articles

Keyword: barcoded-LNPsClear keyword

International journal of nanomedicine2026ResearchNon-viral Gene DeliveryDrug Delivery

1. High-Throughput DNA Barcoding Identifies Lipid Nanoparticles for Lung Delivery of TRAIL-mRNA to Induce Tumor Cell Death in Experimental Metastasis Model

Rodrigues Alves Mt, Da Silva Wn, Azevedo Gv, Carvalho Costa Pa, Silva Gh, Figueiredo Mm, Et Al.

Lipid nanoparticles (LNPs) have enabled the clinical translation of nucleic acid therapeutics, and their composition plays a critical role in organ targeting and route-specific delivery. Intranasal (IN) administration offers direct access to the lungs, while reducing systemic exposure. However, designing LNPs capable of overcoming respiratory tract barriers remains a challenge.

TRAIL-mRNA barcoded-LNPs biodistribution intranasal administration lung metastasis lung transfection

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