Iranian journal of medical sciences2026ResearchNon-viral Gene DeliveryDrug Delivery
1. CRISPR/Cas9-Mediated Targeting of the Integrin Beta-2 Gene as a Gene-Editing Strategy for Leukocyte Adhesion Deficiency Type I
Raji S, Soltaninejad H, Hosseinkhani S, Hamidieh Aa
Leukocyte adhesion deficiency (LAD) is a genetic immunodeficiency that severely impairs the leukocyte adhesion cascade and migration to the sites of infection and inflammation. As a result, the main consequence is recurrent and severe infections with bacteria and fungi, which can lead to death. The most common…
- CRISPR-Cas systems
- Cell-penetrating peptide
- Gene editing
- ITGB2 protein
- Leukocyte adhesion deficiency Type I