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Research Review

Showing 1–1 of 1 articles · Keyword: chronic hepatitis B Clear keyword

Molecular therapy. Nucleic acids2026ReviewNon-viral Gene Delivery

1. Oligonucleotide and RNA-targeted therapeutics for chronic hepatitis B: Antigen reduction, delivery, and functional cure strategies

Meng X, Mahmood F, Li H, Zhou T

Chronic hepatitis B (CHB) remains difficult to cure because nucleos(t)ide analogs suppress hepatitis B virus (HBV) replication but do not eliminate covalently closed circular DNA (cccDNA) or integrated HBV DNA, which sustain viral RNA and hepatitis B surface antigen (HBsAg) production. RNA-targeted therapeutics…

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