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691 articles

Research Review

Showing 1–1 of 1 articles · Keyword: clusterin Clear keyword

Cancer drug resistance (Alhambra, Calif.)2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Randomized multicentre Phase 2 clinical trial of non-viral gene therapy for pancreatic cancer: clinical and molecular findings

Buscail L, Lebrin M, Hanoun N, Gourgou S, Dorat N, Vernejoul F, Et Al.

Aim: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis, and innovative therapies are needed. We developed a phase I pilot, non-viral gene therapy (CYL-02) encoding SST2 and DCK::UMK genes complexed with a polyethyleneimine non-viral vector to sensitize tumours to gemcitabine chemotherapy, which showed…

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