Papers, explained in our own words

1. Human T cell engineering via serial delivery of mRNA encapsulated within lipid nanoparticles

Ramamurthy A, Scimonelli G, Murphy Wl, Saha K

Human T cells modified with nucleic acids constitute a powerful and emerging therapeutic modality for cancer, autoimmune disorders, and aging-related diseases. However, delivering nucleic acids, such as mRNA encoding synthetic receptors, transcription factors, cytokines, or genome editors to T cells can be challenging, as nucleic acids can unintentionally reduce viable T cell yield and function, particularly when delivered sequentially ex vivo .