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571 articles

Research Review

Showing 1–1 of 1 articles · Keyword: endothelial cells Clear keyword

Molecular therapy. Nucleic acids2026ResearchNon-viral Gene DeliveryDrug Delivery

1. LNP-mediated CRISPR gene editing of human vascular endothelial cells in 2D and 3D microfluidic cell culture systems

Olsen Al, Brandt Cbv, Larsen Rk, Fonager Sv, Zubia-Aranburu J, Haskó J, Et Al.

Efficient and cell-type-specific delivery remains a major barrier to CRISPR-based genome editing in vascular endothelial cells. Here, we systematically evaluate lipid nanoparticle (LNP)-mediated mRNA and CRISPR delivery in human umbilical vein endothelial cells (HUVECs). While a conventional SM-102-based LNP…

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