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Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

721 articles

Research Review

Showing 1–2 of 2 articles · Keyword: formulation optimization Clear keyword

Journal of liposome research2026ResearchNon-viral Gene Delivery

1. Optimized cationic lipid microbubbles for ultrasound-triggered gene delivery: formulation, characterization, and in vitro evaluation

Chen S, Wei W, Xing Q, Li W, Feng X, Mai P, Et Al.

The clinical efficacy of non-viral gene therapy is often limited by the low loading capacity of delivery vectors. To address this, we engineered an ultrasound-responsive cationic lipid microbubbles (CLMBs) platform from clinically accepted biocompatible components to maximize nucleic acid encapsulation. The system…

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Pathology, research and practice2026ResearchNon-viral Gene DeliveryDrug Delivery

2. Formulation optimisation of an mRNA-lipid nanoparticle platform sustains in vivo production of the SARS-CoV-2-neutralizing nanobody VHH 72

Dong Y, Li Q, Ou Y, Li M, Liu N, Wang X, Et Al.

Neutralizing antibodies act rapidly against SARS-CoV-2, but monoclonal antibodies are costly to manufacture and single-domain antibodies are cleared rapidly. Here we evaluated an mRNA-lipid nanoparticle (LNP) platform encoding the neutralizing nanobody VHH 72 and optimized the carrier by raising DSPC from 10 to 40…

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