Molecular therapy. Nucleic acids2026ReviewNon-viral Gene Delivery
1. Oligonucleotide and RNA-targeted therapeutics for chronic hepatitis B: Antigen reduction, delivery, and functional cure strategies
Meng X, Mahmood F, Li H, Zhou T
Chronic hepatitis B (CHB) remains difficult to cure because nucleos(t)ide analogs suppress hepatitis B virus (HBV) replication but do not eliminate covalently closed circular DNA (cccDNA) or integrated HBV DNA, which sustain viral RNA and hepatitis B surface antigen (HBsAg) production. RNA-targeted therapeutics…
- HBsAg reduction
- MT: oligonucleotides: therapies and applications
- RNA therapeutics
- antisense oligonucleotide
- chronic hepatitis B
- functional cure
