Pharmaceutics2026ReviewDrug Delivery
1. Beyond Uptake in Cancer Lipid Nanomedicines: Linking Tumour Access, Intracellular Fate, and Molecular Action
Syed Hashim Sa
Clinical translation of lipid nanomedicines in oncology is limited by biological barriers and by an interpretive challenge: tumour accumulation and cellular uptake are often used as proxies for delivery even when pharmacologically competent cargo, meaning cargo capable of producing its intended molecular effect, has…
- RNA therapeutics
- cancer nanomedicine
- endosomal escape
- functional delivery
- intracellular trafficking
- lipid nanoparticles
- liposomes
- protein corona
- target engagement
- transcytosis
