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586 articles

Research Review

Showing 1–1 of 1 articles · Keyword: gene therapies Clear keyword

Advanced healthcare materials2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Exosome-Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi-Chemo Therapy Through Cholesterol-Free, Tumor-Preferential Delivery

Ren Y, Wang Q, Li P, Zhang Z, Wei G, Tan Y, Et Al.

Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are…

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