Articles

Papers, explained in our own words

Every entry summarises what the study set out to test, what it found and why it changes how we design delivery systems. Browse research and reviews or search the collection.

571 articles

Research Review

Showing 1–2 of 2 articles · Keyword: extrahepatic delivery Clear keyword

Advanced healthcare materials2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Exosome-Inspired Proteolipid Nanoparticles Enable Safe, Extrahepatic RNAi-Chemo Therapy Through Cholesterol-Free, Tumor-Preferential Delivery

Ren Y, Wang Q, Li P, Zhang Z, Wei G, Tan Y, Et Al.

Lipid nanoparticle (LNP)-enabled genetic medicines are reshaping cancer therapy yet remain constrained by liver-biased tropism, dose-limiting toxicities, and limited efficacy in refractory solid tumors such as pancreatic ductal adenocarcinoma (PDAC). Here, exosome-inspired proteolipid nanoparticles (Em-pLNPs) are…

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Expert opinion on drug delivery2026ReviewNon-viral Gene DeliveryDrug Delivery

2. siRNA therapeutics: from hepatic delivery to extrahepatic targeting

Wang N, Meng L, Shi Jx, Bartneck M

Small interfering RNA (siRNA) has progressed from an experimental gene-silencing tool to an established therapeutic modality through advances in chemical modification and delivery. Lipid nanoparticles (LNP) and N-acetylgalactosamine (GalNAc)-siRNA conjugates have driven this clinical translation, particularly for…

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