1. Metabolic Nanomedicine Reprograms Mesenchymal Stem Cells for Durable Exosome-Mediated Immunomodulation
Chen J, Zeng K, Chao J, Zhang X, Zhou Z, Li X, Et Al.
Mesenchymal stem cells (MSCs) are widely recognized for their immunomodulatory potential, yet their clinical efficacy remains inconsistent due to poor persistence and functional instability under prolonged inflammatory stress. Here we identify NAD + depletion as a central driver of MSCs exhaustion, leading to…
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