Frontiers in bioengineering and biotechnology2026ReviewNon-viral Gene Delivery
1. The evolving landscape of hybrid viral vector architectures: a persisting niche
Kochergin-Nikitsky K, Smirnikhina S
The development of hybrid viral vectors was historically driven by the need to overcome inherent limitations of individual viral platforms, including restricted payload capacity, narrow tropism, and limited control over genomic persistence. By integrating functional modules from diverse viral and non-viral systems…
- chimeric vectors
- episomal persistence
- gene delivery platforms
- hybrid viral vectors
- packaging capacity
- site-specific integration
- tropism modulation