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Showing 1–1 of 1 articles · Keyword: peptide amphiphiles Clear keyword

ACS applied materials & interfaces2026ResearchNon-viral Gene DeliveryDrug Delivery

1. Integration of Charged Peptide Amphiphiles within Lipid Nanoparticles (LNPs) for Enhanced Targeted mRNA Delivery

Yuan Y, Li G, Liu Y, Liu L, Hu C, Qi H, Et Al.

Lipid nanoparticles (LNPs) play a pivotal role in mRNA-based therapy; however, achieving targeted delivery remains challenging. We developed an LNP platform integrating peptide amphiphiles (PAs) to exploit their dual bioactivity and electrostatic tunability. Two PAs, cationic C16TAT (derived from a cell-penetrating…

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