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421 articles

Keyword: polymeric nanomedicinesClear keyword

International journal of nanomedicine2026ReviewNon-viral Gene DeliveryDrug Delivery

1. Polymeric Nanomedicines for siRNA Delivery in Hepatocellular Carcinoma: Emerging Therapeutic Strategies, Combination Approaches, and Translational Perspectives

Thalij Km, You Hw, Habeeb M, Ratchagar Jv, Khot Vs, Gorde Pl

Hepatocellular carcinoma is the sixth most common cancer worldwide and a leading cause of cancer related mortality. Risk factors include chronic hepatitis B/C, obesity, alcohol abuse, diabetes and metabolic disorders. In advanced stages, normal treatments such as surgery, transplantation and chemotherapy are not as effective as tumors develop resistance and do not target oncogenic pathways well. Small interfering RNA (siRNA) therapeutics have the potential to change treatment paradigms by silencing specific biological pathways, thus suppressing tumor progression.

drug delivery hepatocellular carcinoma polymeric nanomedicines siRNA

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