Journal of biomaterials science. Polymer edition2026ReviewNon-viral Gene DeliveryDrug Delivery
1. Progress in polymeric nanoparticle-based treatment approaches for Wnt β-catenin pathway modulation and adenomatous polyposis coli mutant colorectal cancer
Maheshwari T, Bhattacharya S, Singh D
About 80-90% of sporadic instances of colorectal cancer (CRC) are caused by mutations in the adenomatous polyposis coli (APC) gene, which is one of the earliest and most common molecular events. The constitutive activation of the Wnt/β-catenin signalling pathway caused by APC dysfunction promotes unchecked cellular proliferation, tumour initiation, progression, and treatment resistance.
Colorectal cancer (CRC)PLGA (poly lactic-co-glycolic acid)Wnt/β-catenin signalling pathwayadenomatous polyposis coli (APC) genegene therapy (siRNA, CRISPR/Cas9)polymeric nanoparticles (PNPs)targeted drug delivery
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